Endocrine Abstracts

Introduction: Type 2 diabetes represents an important health problem and is designated by a progressive course. Since the vast majority of type 2 diabetic patients are overweight, there is a need not only to avoid weight gain but to lower body weight. Therefore, the usage of drugs that have the potential to lower body weight (GLP1 RA and SGLT2 -inhibitors) should with metformin be preferred initial therapy in the obese and overweight type 2 diabetic patients.<p class="abst...

Introduction: Type 2 diabetes represents an important health problem and is designated by a progressive course, and the subsequent long-term insulin therapy to achieve optimal glucose control. It is important to stress that a substantial number of patients do not achieve optimal glucose control despite the usage of two doses of premixed insulin. Detemir insulin, along with a low pharmacodynamic coefficient of variability, exhibits anorexigenic features, through its effects on ...

Introduction: Many type 2 diabetes patients continue to have poor glycaemic control and would benefit from insulin therapy. One of the risks that hinders insulin use is hypoglycemia. Optimal insulin therapy should therefore minimize the risk of hypoglycemia while improving glycemic control. Newer insulin preparations degludec and glargin 300 units/ml show more even and prolonged pharmacokinetic profile, enabling an evenly distributed daytime glucose-lowering effect with high r...

Introduction: Growing evidence suggests that nutrients and hormonal signals converge and directly act on brain centers, leading to changes in energy metabolism and stable body weight over time. Catechol O-methyltransferase (COMT) is one of the major enzymes involved in catecholamine and estrogen degradation. There is a well-established association between the COMT Val108/158Met polymorphism and abdominal obesity, blood pressure increase and T2DM. Basal insulin detemir besides ...

Objective: To analyse the semen quality in patients with newly diagnosed lymphoma’s before starting the treatment.Materials and methods: We evaluated semen quality in 131 patient with lymphoma who underwent sperm banking in our clinic over a 14-year period. 102 patients had Hodgkin’s lymphoma, and 29 had non-Hodgkin’s lymphoma. Semen samples were collected by masturbation after 2–7 days of sexual abstinence. Age at banking, semen volu...